Towards a Characterization of Late Talkers: The Developmental Profile of Children with Late Language Emergence through a Web-Based Communicative-Language Assessment

Children acquire language naturally, but there is variation in language acquisition patterns. Indeed, different internal and external variables play a role in acquiring language. However, there are open research questions about the contribution of different variables to language development. Moreover, with societal changes and due to the pandemic situation, there has been a growing interest in testing digitalization related to indirect language acquisition assessment. In this study, a web-based assessment survey was developed to (1) describe the relation between expressive vocabulary, Socio- Conversational Skills (SCS), gender, parental education, executive functions (EFs), and pretend play; (2) determine whether the survey can detect differences between late talkers (LTs) and children with typical language development; (3) identify children with “overall high” and “overall low” communicative-language scores to test the validity of expressive vocabulary as a main indicator to detect LTs. The parents of 108 Italian children (51 males) aged 24–36 months participated in the study. The results showed that expressive vocabulary correlates with measures of SCS (assertiveness and responsiveness) and is reliable in identifying LTs (d = 2.73). Furthermore, SCS and EFs contribute to better characterizing the developmental profile of children aged 24–36 months

CoSMo: a Framework for Implementing Conditioned Process Simulation Models

Process simulation is an analysis tool in process mining that allows users to measure the impact of changes, prevent losses, and update the process without risks or costs. In the literature, several process simulation techniques are available and they are usually built upon process models discovered from a given event log or learned via deep learning. Each group of approaches has its own strengths and limitations. The former is usually restricted to the control-flow but it is more interpretable, whereas the latter is not interpretable by nature but has a greater generalization capability on large event logs. Despite the great performance achieved by deep learning approaches, they are still not suitable to be applied to real scenarios and generate value for users. This issue is mainly due to fact their stochasticity is hard to control. To address this problem, we propose the CoSMo framework for implementing process simulation models fully based on deep learning. This framework enables simulating event logs that satisfy a constraint by conditioning the learning phase of a deep neural network. Throughout experiments, the simulation is validated from both control-flow and data-flow perspectives, demonstrating the proposed framework's capability of simulating cases while satisfying imposed conditions

Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis

Aims: We questioned whether aldosterone and oxidative stress play a role in vascular damage in severe hypertension and investigated the role of Nox1 in this process. Materials and methods: We studied mesenteric arteries, aortas and vascular smooth muscle cells (VSMC) from WKY and SHRSP rats. Vascular effects of eplerenone or canrenoic acid (CA) (mineralocorticoid receptor (MR) blockers), ML171 (Nox1 inhibitor) and EHT1864 (Rac1/2 inhibitor) were assessed. Nox1-knockout mice were also studied. Vessels and VSMCs were probed for Noxs, reactive oxygen species (ROS) and pro-fibrotic/inflammatory signaling. Key findings: Blood pressure and plasma levels of aldosterone and galectin-3 were increased in SHRSP versus WKY. Acetylcholine-induced vasorelaxation was decreased (61% vs 115%) and phenylephrine-induced contraction increased in SHRSP versus WKY (Emax 132.8% vs 96.9%, p < 0.05). Eplerenone, ML171 and EHT1864 attenuated hypercontractility in SHRSP. Vascular expression of collagen, fibronectin, TGFβ, MCP-1, RANTES, MMP2, MMP9 and p66Shc was increased in SHRSP versus WKY. These changes were associated with increased ROS generation, 3-nitrotyrosine expression and Nox1 upregulation. Activation of vascular p66Shc and increased expression of Nox1 and collagen I were prevented by CA in SHRSP. Nox1 expression was increased in aldosterone-stimulated WKY VSMCs, an effect that was amplified in SHRSP VSMCs (5.2vs9.9 fold-increase). ML171 prevented aldosterone-induced VSMC Nox1-ROS production. Aldosterone increased vascular expression of fibronectin and PAI-1 in wild-type mice but not in Nox1-knockout mice. Significance: Our findings suggest that aldosterone, which is increased in SHRSP, induces vascular damage through MR-Nox1-p66Shc-mediated processes that modulate pro-fibrotic and pro-inflammatory signaling pathways

Gender-related variability in information processing of disclosure documents

Disclosure is used worldwide as a tool to increase transparency and help investors to make their decisions, thus partially overcoming asymmetric information in financial markets. This research seeks to explore gender–related variability in visual attention allocation to the Key Investor Information Document, and in the evaluation of product financial attractiveness. We exploited the eye–tracking methodology to collect neural data, responding to the call for considering new data sources. The analysis shows that men tend to dedicate more attention to the sections Objectives and Past performance while women spend more time to scan the sections Risk–reward profile and Costs and charges; when evaluating product financial attractiveness, women, with respect to men, tend to evaluate more often products as poorly financially attractive. Results reveal the existence of gender–related variability in the visual search strategy for relevant information, which, in turn, can impact on the phase of product evaluation. These findings highlight the professional responsibility of regulators and supervisors to monitor sellers’ and marketers’ behaviours when they interact with consumers. Moreover, this study could provide support to develop financial disclosure documents considering individual differences and ensuring that adequate attention is allocated by investors to all financial information sources, thus raising the level of investor protection. Eventually, the study stimulates innovations to be embedded in the world–wide ongoing regulatory developments that aim at increasing transparency requirements

Determinants of invasiveness and ability to cause invasive pneumococcal disease, pneumonia and acute otitis media of different serotypes of Streptococcus pneumoniae

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Neural Correlates of Direct Access Trading in a Real Stock Market: An fMRI Investigation

Background: While financial decision making has been barely explored, no study has previously investigated the neural correlates of individual decisions made by professional traders involved in real stock market negotiations, using their own financial resources. Aim: We sought to detect how different brain areas are modulated by factors like age, expertise, psychological profile (speculative risk seeking or aversion) and, eventually, size and type (Buy/Sell) of stock negotiations, made through Direct Access Trading (DAT) platforms. Subjects and methods: Twenty male traders underwent fMRI while negotiating in the Italian stock market using their own preferred trading platform. Results: At least 20 decision events were collected during each fMRI session. Risk averse traders performed a lower number of financial transactions with respect to risk seekers, with a lower average economic value, but with a higher rate of filled proposals. Activations were observed in cortical and subcortical areas traditionally involved in decision processes, including the ventrolateral and dorsolateral prefrontal cortex (vlPFC, dlPFC), the posterior parietal cortex (PPC), the nucleus accumbens (NAcc), and dorsal striatum. Regression analysis indicated an important role of age in modulating activation of left NAcc, while traders' expertise was negatively related to activation of vlPFC. High value transactions were associated with a stronger activation of the right PPC when subjects' buy rather than sell. The success of the trading activity, based on a large number of filled transactions, was related with higher activation of vlPFC and dlPFC. Independent of chronological and professional age, traders differed in their attitude to DAT, with distinct brain activity profiles being detectable during fMRI sessions. Those subjects who described themselves as very self-confident, showed a lower or absent activation of both the caudate nucleus and the dlPFC, while more reflexive traders showed greater activation of areas involved in strategic decision making. Discussion: The neural correlates in DAT are similar to those observed in other decision making contexts. Trading is handled as a well-learned automatic behavior by expert traders; for those who mostly rely on heuristics, cognitive effort decreases, and transaction speed increases, but decision efficiency lowers following a poor involvement of the dlPFC

Anchoring effect in visual information processing during financial decisions: an eye-tracking study

When reading a financial disclosure document, subjects are faced with multiple information cues and might simplify decisional complexity by relying on heuristics. This study explores whether, in an attempt to filter information from the Payment Account Fees Information Document (FID), subjects anchor their evaluation to a specific item, leading to biased financial choices. By detecting the visual search strategy in 70 subjects through eye tracking, we observed that people exhibited systematic visual anchoring to the top of the document, which corresponds to the Liquidity section that displays the Annual Fee. Moreover, data revealed that subjects sometimes fail to recognize the most advantageous products. This mainly occurs when the Annual Fee is high, even if the other charges compensate for that amount, clarifying the link between visual search strategy and financial decisions. Data also showed the role of financial literacy in modulating attention, as poorly financially literate subjects are more prone to anchoring bias. The findings contribute to the neuroeconomics literature on anchoring effect and highlight practical implications for financial regulators and managers involved in the ergonomics of documents

War, human rights, and medical scientific publishing: European Journal of Physical and Rehabilitation Medicine will accept from now on only papers by authors signing the UN Declaration on Human Rights

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Monitoring of masonry historical constructions: 10 years of static monitoring of the world's largest oval dome

This paper presents the analyses conducted on the data acquired by the monitoring system of the “Regina Montis Regalis” Basilica of Vicoforte (Italy) in the decade 2004–2014. The Basilica is a building of great historical, architectural, and structural significance, owing its fame to its impressive masonry oval dome, the world's largest of this shape (internal axes of 37.23 by 24.89 m). The dome-drum system of the Basilica has suffered over the years of significant structural problems, partly due to the settlements of the building induced progressively by newly built masses and also to the sliding of the underground. In 1983, concerns over the severe settlements and cracking phenomena affecting the structure prompted the decision to undertake strengthening interventions. A special hooping system, consisting of 56 tie bars, placed around the oval perimeter of the dome, was thus conceived to limit the crack opening. The monitoring system of the Basilica installed in the early 1980s underwent several renovations, and in 2004, its acquisition procedure was automatized. One hundred twelve instruments, consisting of temperature sensors, crackmeters, load cells, pressure cells, wire gauges, hygrometer, piezometers, and hydrometer, are currently installed on the Basilica. This study is primarily focused on data acquired by the crackmeters, the extensometers along the main axes of dome, and the load cells placed at the ends of the tie bars. The main aim of the reported analysis is to evaluate the possible progression of the cracks on the Basilica, and the structural performance of the strengthening interventions put in place in 1985–1987